Laryngo-oculo-cutaneous syndrome
(LOC), or Shabbir’s syndrome, presents at birth with blistering and erosions
that typically favors the head and neck. Nail dystrophy and granulation tissue
commonly are observed, while milia and scarring are less common. LOC is
predominantly reported in the state of Punjab, India. Oral erosions, dental
enamel problems, dental caries, and ocular (eye) erosions and other
complications are common. Laryngeal erosions and related complications are a
key feature and may lead to airway obstruction and death. Growth retardation
and anemia may occur, but problems with the intestines/gastrointestinal tract
or genitourinary tract have not been reported.
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