Dowling-Meara EB Simplex

Dowling-Meara EB Simplex is the most severe type of EBS. Where children experience widespread of blistering across their entire body. With more blisters it can make their skin more vulnerable to infection and affect an infant's normal feeding pattern. With more sore on the feet it can make a child a late walker. Blisters can develop inside the mouth and throat, That could make it hard to eat and sometimes speaking. you could have thickening or loss of fingernails and toenails.

The Symptoms of Dowling-Meara EBS usually develop at birth, but the blistering tendency gradually improves through childhood and adolescence. Adults with this form of EBS may only get occasional blistering. However, it is common for the skin on the palms and soles to become thicker with age.

Köbner type EB Simplex (generalized)

This type of form of generalized EB Simplex, blisters can form anywhere on the body in response to friction or trauma.

The symptoms of this type of EBS are also usually more troublesome during hot weather.

They can get blisters inside of the nose, mouth and throats. you could get some scarring but it is uncommon for this type of EB.

The symptoms of this form of EBS usually begin during birth or infancy. Just like the localized EBS, adults may experience thickening of the skin on the palms and sole of their feet, and their fingernails and toenails.

Localized (Weber-Cockayne) EB Simplex

Localized EB Simplex is the most common form of EBS. It is characterized by blisters on the palms of the hands and soles of the feet. They develop after mild or moderate physical activity, such as walking for a long time or playing sport.

Although the sores often form on the hands and feet, it is not uncommon for them to develop on other parts of the body, such as the buttocks or inner things.

The symptoms usually become apparent during early childhood, although mild cases may go undiagnosed until early adolescence.

Some adults with localized EBS may experience thickening of the skin on their palms and soles of their feet, as well as their fingernails and toenails.

EB simplex

The blistering occurs right above the basement of the membrane. Approximately 70% of people with EB will have EB simplex.  Most types of EB Simplex are inherited, as a dominant trait. This means that one of the parents has the condition or it runs in the family. Having the condition in the family history there is a possibility of having a child with EB simplex. The most common form of EB Simplex just has blistering to their hands and feet. Patients usually do not seek medical assistance because it is so mild and it well known in the family, because it is a dominant inheritance. There is about five other types of EB Simplex. With the other types of EB simplex the blistering can occur all over the body.

Types of EB!

EB is divided into three main types: EB Simplex, Junctional EB and Dystorphic EB. The way it is divided is based on the location of the disruption, that would be in the basement of the membrane of the skin. The location of the defect determines the symptoms of each type of EB. In every main type it can by divided again into several variations and currently, 27 clinical sub-types are known.

The Genetic part of EB!

EB is genetic that mean our DNA is different than yours. When people are born with EB they are born missing the glue that holds their skin together. Most people with EB have inherited the condition.  They received the genes that makes the abnormalities in the skin from one or both parents. What that means we have different types of protein in the skin, including collagen and keratin. If any of these proteins are bad, our skin becomes fragile like a butterfly wing.  

what EB stands for!

(EB) stands for (Epidermolysis Bullosa). (EB) is a rare skin condition, and it is not contagious or a diseases. The outer layer of the skin is called 'epidermis' and the inner layer of the skin is call (dermis). 'Lysis' means breakdown. 'Epidermolysis' just means breakdown of the epidermis.  'Bullosa' is just another word for blister.