Localized (Weber-Cockayne) EB Simplex

Localized EB Simplex is the most common form of EBS. It is characterized by blisters on the palms of the hands and soles of the feet. They develop after mild or moderate physical activity, such as walking for a long time or playing sport.

Although the sores often form on the hands and feet, it is not uncommon for them to develop on other parts of the body, such as the buttocks or inner things.

The symptoms usually become apparent during early childhood, although mild cases may go undiagnosed until early adolescence.

Some adults with localized EBS may experience thickening of the skin on their palms and soles of their feet, as well as their fingernails and toenails.